S.No.	Sequence_definition	HRE_location_on_sequence	HRE sequence	HRE (A|G)CGTG)	HAS (CA(C|G)(A|G)(T|G|C))
1	>igfbp1, Takifugu rubripes, NC_018911.1, minus Geneid: 101074885	1144..1174	ACGTGAGAAGCAGGCAGAGGAAAAAACAAA	ACGTG	CAGAG
2	>igfbp1, Takifugu rubripes, NC_018911.1, minus Geneid: 101074885	2631..2661	GCGTGGGCACCGTGACCACATCTTCAGTGG	GCGTG	CACAT
3	>igfbp1, Takifugu rubripes, NC_018911.1, minus Geneid: 101074885	4143..4173	GCGTGGGTGAGCACAGCACAGAATCTGATC	GCGTG	CACAG
4	>igfbp1a, Danio rerio, NC_007131.6, minus Geneid: 317638	86..116	GCGTGTGCTGACGCTCACAGGCTGTTTCAC	GCGTG	CAGGC

Functional HRE in reverse strand 
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S.No.	Sequence_definition	HRE_location_on_sequence	HRE sequence	HRE (A|G)CGTG)	HAS (CA(C|G)(A|G)(T|G|C))
1	>IGFBP1, Homo sapiens, NC_000007.14, plus Geneid: 3484	882..912	GCGTGCCATGCTCCAGGCCTGCCCCTTGGT	GCGTG	CAGGC
2	>igfbp1, Takifugu rubripes, NC_018911.1, minus Geneid: 101074885	4057..4087	ACGTGGGCCGTGTCCATCTCAGAGACACGA	ACGTG	CAGAG
3	>igfbp1a, Danio rerio, NC_007131.6, minus Geneid: 317638	1192..1222	ACGTGACCTCACTCAGGTCAGGACGGCACC	ACGTG	CAGGT